By Frederick J Ehlert
The interplay of a drug with a receptor generates a code of data having parts of affinity and efficacy. How this data is translated right into a reaction is determined by the original cells, tissue, organ or approach during which the receptor is living. This publication describes easy methods to study a number of responses to estimate the affinity and efficacy elements of the preliminary drug–receptor interplay. extra in particular, it describes the right way to degree the affinity and efficacy of gear during the research of unmarried receptor task, the activation kingdom of a inhabitants of receptors, and responses downstream from receptor activation. extra mild is thrown on ligand-gated ion channels and G protein-coupled receptors during this book.
The themes mentioned comprise radioligand binding, estimation of agonist affinity and efficacy, aggressive antagonism, inverse agonism, allosteric agonists and modulators, agonist bias, modulation of pathway selectivity, and the estimation of ligand affinity for lively and inactive receptor states. The common background and constitution of ligand-gated ion channels, G proteins, and G protein-coupled receptors also are discussed.
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Extra resources for Affinity and Efficacy:The Components of Drug-Receptor Interactions
Affinity and Efficacy:The Components of Drug-Receptor Interactions by Frederick J Ehlert